Nicola J Curtin Selected Research

NU 3153

7/2009

Preclinical evaluation of a novel pyrimidopyrimidine for the prevention of nucleoside and nucleobase reversal of antifolate cytotoxicity.

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Nicola J Curtin Research Topics

Disease

52	Neoplasms (Cancer) 01/2022 - 10/2002
10	Ovarian Neoplasms (Ovarian Cancer) 03/2021 - 04/2010
7	Ataxia Telangiectasia (Louis Bar Syndrome) 04/2020 - 12/2004
7	Breast Neoplasms (Breast Cancer) 03/2018 - 09/2008
4	Neuroblastoma 12/2021 - 02/2009
4	Colonic Neoplasms (Colon Cancer) 01/2016 - 05/2006
2	Ascites 03/2019 - 01/2016
2	Carcinoma (Carcinomatosis) 01/2018 - 07/2003
2	Leukemia 01/2018 - 12/2005
2	Hepatocellular Carcinoma (Hepatoma) 01/2016 - 02/2015
2	Glioblastoma (Glioblastoma Multiforme) 12/2015 - 02/2009
2	Hypersensitivity (Allergy) 10/2015 - 12/2004
2	Sarcoma (Soft Tissue Sarcoma) 09/2010 - 03/2005
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2018
1	Hematologic Neoplasms (Hematological Malignancy) 01/2017
1	Uterine Cervical Neoplasms (Cancer of the Cervix) 05/2016
1	Brain Neoplasms (Brain Tumor) 12/2015
1	Liver Diseases (Liver Disease) 02/2015
1	Ewing Sarcoma (Sarcoma, Ewing) 07/2014
1	Stomach Neoplasms (Stomach Cancer) 01/2014
1	Neoplasm Metastasis (Metastasis) 10/2013
1	Ovarian Epithelial Carcinoma 11/2012
1	Cardiotoxicity 12/2011
1	Prostatic Neoplasms (Prostate Cancer) 01/2011
1	Genomic Instability 09/2010

Drug/Important Bio-Agent (IBA)

24	Poly(ADP-ribose) Polymerase InhibitorsIBA 03/2021 - 03/2005
19	DNA (Deoxyribonucleic Acid)IBA 02/2016 - 01/2004
11	Biomarkers (Surrogate Marker)IBA 03/2021 - 10/2013
11	rucaparibIBA 03/2019 - 02/2009
11	Temozolomide (Temodar)FDA LinkGeneric 09/2017 - 07/2003
9	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 04/2020 - 04/2010
8	Phosphotransferases (Kinase)IBA 01/2020 - 12/2004
8	Pharmaceutical PreparationsIBA 03/2018 - 10/2009
4	PlatinumIBA 03/2021 - 08/2010
4	lysyl- arginyl- alanyl- lysyl- alanyl- lysyl- threonyl- threonyl- lysyl- lysyl- arginine (PKCS)IBA 02/2016 - 08/2012
4	Proteins (Proteins, Gene)FDA Link 01/2016 - 05/2005
4	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2014 - 09/2010
4	Poly (ADP-Ribose) Polymerase-1IBA 06/2011 - 05/2005
4	EnzymesIBA 09/2010 - 07/2002
3	A-Form DNA (A-DNA)IBA 04/2020 - 04/2005
3	8- dibenzothiophen- 4- yl- 2- morpholin- 4- yl- chromen- 4- oneIBA 01/2014 - 05/2006
3	1,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA 01/2014 - 08/2010
3	PoisonsIBA 06/2013 - 01/2004
3	Etoposide (VP 16)FDA LinkGeneric 06/2013 - 05/2006
3	1- (4- dimethylaminomethylphenyl)- 8,9- dihydro- 7H- 2,7,9a- benzo(cd)azulen- 6- oneIBA 10/2009 - 01/2004
3	Topotecan (Hycamtin)FDA LinkGeneric 02/2009 - 07/2003
2	dactolisibIBA 01/2019 - 01/2016
2	Small Interfering RNA (siRNA)IBA 03/2018 - 12/2008
2	V158411IBA 02/2016 - 01/2016
2	Serine (L-Serine)FDA Link 02/2016 - 03/2015
2	3- amino- 6- (4- (methylsulfonyl)phenyl)- N- phenylpyrazine- 2- carboxamideIBA 10/2015 - 03/2015
2	CamptothecinIBA 06/2013 - 12/2005
2	Type I DNA Topoisomerases (Topoisomerase I)IBA 06/2013 - 01/2004
2	ProdrugsIBA 09/2011 - 07/2002
2	Cisplatin (Platino)FDA LinkGeneric 08/2010 - 01/2005
2	Cytotoxins (Cytolysins)IBA 07/2003 - 11/2002
1	Discoidin Domain ReceptorsIBA 04/2020
1	Cyclin EIBA 01/2020
1	olaparibIBA 01/2019
1	Glutamine (L-Glutamine)FDA Link 01/2019
1	Imatinib Mesylate (Gleevec)FDA Link 01/2019
1	VS-5584IBA 01/2019
1	Glucose (Dextrose)FDA LinkGeneric 01/2019
1	Phosphoglycerate Dehydrogenase (Dehydrogenase, Phosphoglycerate)IBA 03/2018
1	berzosertibIBA 01/2018
1	Ribonucleotide Reductases (Ribonucleotide Reductase)IBA 01/2018
1	Protein Kinases (Protein Kinase)IBA 01/2018
1	NucleosidesIBA 01/2018
1	Gemcitabine FDA Link 01/2018
1	Keratins (Keratin)IBA 01/2018
1	VimentinIBA 01/2018
1	Checkpoint Kinase 1IBA 04/2017
1	talazoparibIBA 01/2017
1	Cell ExtractsIBA 01/2017
1	Adenosine Diphosphate (ADP)IBA 05/2016
1	Adenosine Diphosphate Ribose (ADP-Ribose)IBA 05/2016
1	PTEN Phosphohydrolase (PTEN Phosphatase)IBA 02/2016
1	MTOR InhibitorsIBA 01/2016
1	(5- (2,4- bis((3S)- 3- methylmorpholin- 4- yl)pyrido(2,3- d)pyrimidin- 7- yl)- 2- methoxyphenyl)methanolIBA 01/2016
1	Sirolimus (Rapamycin)FDA Link 01/2016
1	Biological ProductsIBA 03/2015
1	Messenger RNA (mRNA)IBA 03/2015
1	EWS-FLI fusion proteinIBA 07/2014
1	Oncogene Proteins (Oncogene Protein)IBA 07/2014
1	Topoisomerase InhibitorsIBA 12/2013
1	KU59403IBA 06/2013
1	Phosphatidylinositol 3-Kinases (PI 3 Kinase)IBA 08/2012
1	2- (4- ethylpiperazin- 1- yl)- N- (4- (2- morpholino- 4- oxo- 4H- chromen- 8- yl)dibenzo(b,d)thiophen- 1- yl)acetamideIBA 08/2012
1	DNA Repair EnzymesIBA 12/2011
1	Cyclin-Dependent Kinase 2IBA 09/2011
1	NU6102IBA 09/2011
1	Carboplatin (JM8)FDA LinkGeneric 02/2011
1	Hormones (Hormone)IBA 01/2011
1	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 08/2010
1	Thioguanine (Tioguanine)FDA Link 08/2010
1	Niacinamide (Nicotinamide)FDA LinkGeneric 10/2009

Therapy/Procedure

19	Therapeutics 12/2021 - 03/2005
10	Drug Therapy (Chemotherapy) 03/2021 - 01/2004
6	Radiotherapy 01/2022 - 01/2004
1	Lasers (Laser) 12/2015